Annotate already loaded proteins and transcripts direct from Clinvar

NCBI Clinvar's web api provides the most up to date route for obtaining biomedically relevant mutation data, and often other sources lag behind (including ClinVar's own ftp site which provides VCF, etc).

Full variant details for specific entries are available by eUtils:
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=clinvar&id=48074&rettype=variation

It also looks like a VCF or TSV dump can be obtained for a gene.
docs here: https://www.ncbi.nlm.nih.gov/clinvar/docs/maintenance_use/